PUBLICATIONS

2025

“Host metabolism balances microbial regulation of bile acid signalling”

Tae Hyung Won, Mohammad Arifuzzaman, Christopher N. Parkhurst, Isabella C. Miranda, Bingsen Zhang, Elin Hu, Sanchita Kashyap, Jeffrey Letourneau, Wen-Bing Jin, Yousi Fu, Douglas V. Guzior, JRI Live Cell Bank, Robert A. Quinn, Chun-Jun Guo, Lawrence A. David, David Artis, Frank C. Schroeder

Nature, Vol. 638, 2025

“Grocery intervention and DNA-based assessment to improve diet quality in pediatric obesity: a pilot randomized controlled study”

Ammara Aqeel, Melissa C. Kay, Jun Zeng, Brianna L. Petrone, Chengxin Yang, Tracy Truong, Covington B. Brown, Sharon Jiang, Veronica M. Carrion, Stephanie Bryant, Michelle C. Kirtley, Cody D. Neshteruk, Sarah C. Armstrong, Lawrence A. David

Obesity, Vol. 33, No. 2, 2025

2024

“Weight, habitual fibre intake, and microbiome composition predict tolerance to fructan supplementation”

Jeffrey Letourneau, Benjamin C. Neubert, Diana Dayal, Verónica M. Carrion, Heather K. Durand, Eric P. Dallow, Sharon Jiang, Michelle Kirtley, Geoffrey S. Ginsburg, P. Murali Doraiswamy, and Lawrence A. David

International Journal of Food Sciences and Nutrition, Vol. 75, No. 6, 2024

“Interplay between particle size and microbial ecology in the gut microbiome”

Jeffrey Letourneau, Verónica M Carrion, Jun Zeng, Sharon Jiang, Olivia W Osborne, Zachary C Holmes, Aiden Fox, Piper Epstein, Chin Yee Tan, Michelle Kirtley, Neeraj K Surana, and Lawrence A David

The ISME Journal, Vol. 18, No. 1, 2024

“The Binding Properties of Antibodies to Z-DNA in the Sera of Normal Healthy Subjects”

David S. Pisetsky, Matthew J. Gedye, Lawrence A. David, and Diane M. Spencer

International Journal of Molecular Sciences, Vol. 18, No. 1, 2024

“Ultra-processed food intake, gut microbiome, and glucose homeostasis in mid-life adults: Background, design, and methods of a controlled feeding trial”

Bailey T. Capra, Summer Hudson, McKenna Helder, Eleni Laskaridou, Aubrey L. Johnson, Carson Gilmore, Elaina Marinik, Valisa E. Hedrick, Jyoti Savla, Lawrence A. David, Kevin P. Davy, and Brenda M. Davy

Contemporary Clinical Trials, No. 137, 2024

“A pilot study of fecal pH and redox as functional markers in the premature infant gut microbiome”

Jeffrey Letourneau, LaShawndra Walker, Se Hyang Han, Lawrence A. David, andNoelle Younge

PLOS ONE, Vol. 19, No. 1, 2024

2023

“A genetic system for Akkermansia muciniphila reveals a role for mucin foraging in gut colonization and host sterol biosynthesis gene expression”

Lauren E. Davey, Per N. Malkus, Max Villa, Lee Dolat, Zachary C. Holmes, Jeff Letourneau, Eduard Ansaldo, Lawrence A. David, Gregory M. Barton, and Raphael H. Valdivia

Nature Microbiology, Vol. 8, No. 8, 2023

“Diversity of plant DNA in stool is linked to dietary quality, age, and household income”

Brianna L. Petrone, Ammara Aqeel, Sharon Jiang, Heather K. Durand, Eric P. Dallow, Jessica R. McCann, Holly K. Dressman, Zhengzheng Hu, Christine B. Tenekjian, William S. Yancy Jr., Pao-Hwa Lin, Julia J. Scialla, Patrick C. Seed, John F. Rawls, Sarah C. Armstrong, June Stevens, and Lawrence A. David

PNAS, Vol. 120, No. 27, 2023

2022

"Prebiotic galactooligosaccharides interact with mouse gut microbiota to attenuate acute graft-versus-host disease”

Zachary C. Holmes, Helen Tang, Congxiao Liu, Amy Bush, Benjamin C. Neubert, Yiqun Jiao, Megan Covington, Diana M. Cardona, Michelle C. Kirtley, Benny J. Chen, Nelson J. Chao, Lawrence A. David, and Anthony D. Sung

Blood, American Society of Hematology, Vol. 140, No. 1 21, 2022

“Ecological memory of prior nutrient exposure in the human gut microbiome”

Jeffrey Letourneau, Zachary C Holmes, Eric P Dallow, Heather K Durand, Sharon Jiang, Verónica M Carrion, Savita K Gupta, Adam C Mincey, Michael J Muehlbauer, James R Bain, and Lawrence A David

The ISME Journal, Vol. 16, No. 11, 2022

"Horizontal gene transfer enables programmable gene stability in synthetic microbiota”

Teng Wang, Andrea Weiss, Ammara Aqeel, Feilun Wu, Allison J. Lopatkin, Lawrence A. David, and Lingchong You

Nature Chemical Biology, Vol. 18, No. 11, 2022

“Microbiota responses to different prebiotics are conserved within individuals and associated with habitual fiber intake”

Zachary C. Holmes, Max M. Villa, Heather K. Durand, Sharon Jiang, Eric P. Dallow, Brianna L. Petrone, Justin D. Silverman, Pao-Hwa Lin, and Lawrence A. David

Microbiome, No. 10, 2022

“Modulation of microbial community dynamics by spatial partitioning”

Feilun Wu, Yuanchi Ha, Andrea Weiss, Meidi Wang, Jeffrey Letourneau, Shangying Wang, Nan Luo, Shuquan Huang, Charlotte T. Lee, Lawrence A. David, and Lingchong You

Nature Chemical Biology, Vol. 18, No. 4, 2022

“Conceptual Exchanges for Understanding Free-Living and Host-Associated Microbiomes”

Catherine A. Pfister, Samuel H. Light, Brendan Bohannan, Thomas Schmidt, Adam Martiny, Nicole A. Hynson, Suzanne Devkota, Lawrence David, and Katrine Whiteson

mSystems (ASM Journals), Vol. 7, No. 1, 2022

“Bayesian Multinomial Logistic Normal Models through Marginally Latent Matrix-T Processes”

Justin D. Silverman, Kimberly Roche, Zachary C. Holmes, Lawrence A. David, and Sayan Mukherjee

Journal of Machine Learning Research, Vol. 23, 2022

2021

“Measuring and mitigating PCR bias in microbiota datasets”

Justin D. Silverman, Rachael J. Bloom, Sharon Jiang, Heather K. Durand, Eric Dallow, Sayan Mukherjee, and Lawrence A. David

PLoS Computational Biology, Vol. 17, No. 7, 2021

“Genotypic and Phenotypic Diversity among Human Isolates of Akkermansia muciniphila

Bradford Becken, Lauren Davey, Dustin R. Middleton, Katherine D. Mueller, Agastya Sharma, Zachary C. Holmes, Eric Dallow, Brenna Remick, Gregory M. Barton, Lawrence A. David, Jessica R. McCann, Sarah C. Armstrong, Per Malkus, and Raphael H. Valdivia

mBio (ASM Journals), Vol. 12, No. 3, 2021

The Pediatric Obesity Microbiome and Metabolism Study (POMMS): Methods, Baseline Data, and Early Insights

Jessica R. McCann, Nathan A. Bihlmeyer, Kimberly Roche, Cameron Catherine, Jayanth Jawahar, Lydia Coulter Kwee, Noelle E. Younge, Justin Silverman, Olga Ilkayeva, Charles Sarria, Alexandra Zizzi, Janet Wootton, Lisa Poppe, Paul Anderson, Michelle Arlotto, Zhengzheng Wei, Joshua A. Granek, Raphael H. Valdivia, Lawrence A. David, Holly K. Dressman, Christopher B. Newgard, Svati H. Shah, Patrick C. Seed, John F. Rawls, and Sarah C. Armstrong

Obesity, Vol. 29, No. 3, 2021

Predicting Vibrio cholerae Infection and Disease Severity Using Metagenomics in a Prospective Cohort Study

Inès Levade, Morteza M Saber, Firas S Midani, Fahima Chowdhury, Ashraful I Khan, Yasmin A Begum, Edward T Ryan, Lawrence A David, Stephen B Calderwood, Jason B Harris, Regina C LaRocque, Firdausi Qadri, B Jesse Shapiro, and Ana A Weil

Journal of Infectious Diseases, Vol. 223, No. 2, 2021

“Individual Variation in Prebiotic Response”

Lawrence A. David, Zachary C. Holme1, Max M. Villa, Heather K. Durand, Sharon Jiang, Eric P. Dallow, Brianna L. Petrone, Justin D. Silverman, and Pao-Hwa Lin

In Vitro Cellular & Developmental Biology, Vol. 57, No. 1, 2021

2020

Conserved anti-inflammatory effects and sensing of butyrate in zebrafish

Pradeep Manuneedhi Cholan, Alvin Han, Brad R Woodie, Maxinne Watchon, Angela RM Kurz, Angela S Laird, Warwick J Britton, Lihua Ye, Zachary C Holmes, Jessica R McCann, Lawrence A David, John F Rawls, and Stefan H Oehlers

Gut Microbes, Vol. 20, No. 1, 2020

Short-Chain Fatty Acid Production by Gut Microbiota from Children with Obesity Differs According to Prebiotic Choice and Bacterial Community Composition

Zachary C. Holmes, Justin D. Silverman, Holly K. Dressman, Zhengzheng Wei, Eric P. Dallow, Sarah C. Armstrong, Patrick C. Seed, John F. Rawls, and Lawrence A. David

mBio (ASM Journals), Vol. 11, No. 4, 2020

Interindividual Variation in Dietary Carbohydrate Metabolism by Gut Bacteria Revealed with Droplet Microfluidic Culture

Max M. Villa, Rachael J. Bloom, Justin D. Silverman, Heather K. Durand, Sharon Jiang, Anchi Wu, Eric P. Dallow, Shuqiang Huang, Lingchong You, and Lawrence A. David

mSystems (ASM Journals), Vol. 5, No. 3, 2020

“The emergence of microbiome centres”

Jennifer B. H. Martiny, Katrine L. Whiteson, Brendan J. M. Bohannan, Lawrence A. David, Nicole A. Hynson, Margaret McFall-Ngai, John F. Rawls, Thomas M. Schmidt, Zaid Abdo, Martin J. Blaser, Seth Bordenstein, Christian Bréchot, Carolee T. Bull, Pieter Dorrestein, Jonathan A. Eisen, Ferran Garcia-Pichel, Jack Gilbert, Kirsten S. Hofmockel, Mary L. Holtz, Rob Knight, David B. Mark Welch, Daniel McDonald, Barbara Methé, Nigel J. Mouncey, Noel T. Mueller, Catherine A. Pfister, Lita Proctor, and Joel L. Sachs

Nature Microbiology, Vol. 5, No. 1, 2020

Naught all zeros in sequence count data are the same

Justin D. Silverman, Kimberly Roche, Sayan Mukherjee, and Lawrence A. David

Computational and Structural Biotechnology Journal, Vol. 18, 2020

2019

“Using DNA Metabarcoding To Evaluate the Plant Component of Human Diets: a Proof of Concept”

Aspen T. Reese, Tyler R. Kartzinel, Brianna L. Petrone, Peter J. Turnbaugh, Robert M. Pringle, Lawrence A. David

mSystems (ASM Journals), Vol. 4, No. 5, 2019

“Phylofactorization: a graph partitioning algorithm to identify phylogenetic scales of ecological data”

Alex D. Washburne, Justin D. Silverman, James T. Morton, Daniel J. Becker, Daniel Crowley, Sayan Mukherjee, Lawrence A. David, Raina K. Plowright"

Ecological Monographs, Vol. 89, No. 2, 2019

Personalizing Medicine to the Microbiome

Lawrence David

FASEB Journal, Vol. 33, No. S1, 2019

2018

Microbial nitrogen limitation in the mammalian large intestine

Aspen T. Reese, Fátima C. Pereira, Arno Schintlmeister, David Berry, Michael Wagner, Laura P. Hale, Anchi Wu, Sharon Jiang, Heather K. Durand, Xiyou Zhou, Richard T. Premont, Anna Mae Diehl, Thomas M. O’Connell, Susan C. Alberts, Tyler R. Kartzinel, Robert M. Pringle, Robert R. Dunn, Justin P. Wright & Lawrence A. David

Nature Microbiology, Vol. 3, No. 12, 2018

Dynamic linear models guide design and analysis of microbiota studies within artificial human guts

Justin D. Silverman, Heather K. Durand, Rachael J. Bloom, Sayan Mukherjee, Lawrence A. David

Microbiome, Vol. 6, No. 1, 2018

Human Gut Microbiota Predicts Susceptibility to Vibrio cholerae Infection

Firas S. Midani, Ana A. Weil, Fahima Chowdhury, Yasmin A. Begum, Ashraful I Khan, Meti D. Debela, Heather K. Durand, Aspen T. Reese, Sai N. Nimmagadda, Justin D. Silverman, Crystal N. Ellis, Edward T. Ryan, Stephen B. Calderwood, Jason B. Harris, Firdausi Qadri, Lawrence A. David, Regina C. LaRocque

Journal of Infectious Diseases, Vol. 218, No. 4, 2018

Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut

Aspen T. Reese, Eugenia H. Cho, Bruce Klitzman, Scott P. Nichols, Natalie A. Wisniewski, Max M. Villa, Heather K. Durand, Sharon Jiang, Firas S. Midani, Sai N. Nimmagadda, Thomas M. O'Connell, Justin P. Wright, Marc A. Deshusses, Lawrence A. David

eLife, Vol. 7, 2018

Plant community and soil conditions individually affect soil microbial community assembly in experimental mesocosms

Aspen T. Reese, Kyrstin Lulow, Lawrence A. David, Justin P. Wright

Ecology and Evolution, Vol. 8, No. 2, 2018

Toward Personalized Control of Human Gut Bacterial Communities

Aspen T. Reese, Kyrstin Lulow, Lawrence A. David, Justin P. Wright

mSystems (ASM Journals), Vol. 3, No. 2, 2018